How to Pick a Starting Loadout and Build Toward Overpowered Runs

This isn't a repeat of the Overview page -- it's a practical look at choosing Starting Loadouts and building toward game-breaking synergies, based on official materials ahead of launch.

Weigh Vulnerabilities as Seriously as Perks

Since Starting Loadouts are confirmed to pair massive perks with genuinely devastating vulnerabilities, read the full tradeoff before committing -- a loadout that looks powerful on paper may create real problems if its vulnerability doesn't match your intended strategy.

Learn Tile Modifiers Before Chasing Synergy

Since Tile Modifiers are confirmed to fundamentally change movement, manipulation, and destruction mechanics, build a real understanding of individual modifiers before trying to combine them into complex synergies -- the depth is confirmed to be genuine, not just cosmetic variety.

Prioritize Artifacts and Pip Cores With a Direction in Mind

Since collecting Artifacts, Pip Cores, and new dominoes is confirmed as the path to breaking the game's systems, decide roughly what kind of overpowered build you're chasing rather than collecting reactively without a plan.

Adapt to Each Dynamic Board

Since boards are confirmed to be procedurally generated from countless Board Archetypes, treat every new board as a genuine reset in strategy rather than assuming your previous run's approach will transfer directly.

See the full data: Dominocalypse Items